Timed Lab 公募ラボ

Laboratory of Neuropharmacology

神経薬理学ラボ

Laboratory of Neuropharmacology

神経薬理学ラボ

PI: 

    Yamada, Maki K., Professor

    ORCID:   URL: https://orcid.org/0000-0002-1956-6069

    Researchmap: URL: https://researchmap.jp/makiyamada

    Researchgate: URL: https://www.researchgate.net/profile/Maki-Yamada 

Member

Nakatsuma, Aya, PhD, Lecturer

Kubota, Takeshi, PhD, Assistant Professor

Visiting Scientist

    Yamamoto, Tohru, PhD, Professor, Kagawa University

 

構成員

主宰者

    山田 麻紀 教授

メンバー

    中妻 彩 講師

    窪田 剛志 助教 

客員研究員

    山本 融 教授(香川大学・医学部)


最近5年間の論文と代表論文

Maki K Yamada

Google scholar https://scholar.google.com/citations?user=2Q1LCxkAAAAJ&hl=en


[Original papers]

1.    Kuboyama K, Inoue T, Hashimotodani Y, (7 students), Gusain P, Kano M, and Yamada MK. Traceable stimulus-dependent rapid molecular changes in dendritic spines in the brain. Scientific reports. 2020;10(1):15266.

 

2.    Kuboyama K, Shirakawa Y, Kawada K, Fujii N, Ojima D, Kishimoto Y, Yamamoto T, and Yamada MK. Visually cued fear conditioning test for memory impairment related to cortical function. Neuropsychopharmacol Rep. 2020;40(4):371-375.


3.    Ikeda T, Makino Y, Yamada MK. 17alpha-estradiol is generated locally in the male rat brain and can regulate GAD65 expression and anxiety. Neuropharmacology. 2015;90:9-14.


4.    Peng YR, Zeng SY, Song HL, Li MY, Yamada MK, and Yu X. Postsynaptic spiking homeostatically induces cell-autonomous regulation of inhibitory inputs via retrograde signaling. J Neurosci. 2010;30(48):16220-16231.


5.    Tamura M, Tamura N, Ikeda T, Koyama R, Ikegaya Y, Matsuki N, and Yamada MK. Influence of brain-derived neurotrophic factor on pathfinding of dentate granule cell axons, the hippocampal mossy fibers. Mol Brain. 2009;2:2.


6.    Kitanishi T, Ikegaya Y, Matsuki N, and Yamada MK. Experience-Dependent, Rapid Structural Changes in Hippocampal Pyramidal Cell Spines. Cerebral cortex.  2009;19(11):2572-2578.


7.    Ohba S, Ikeda T, Ikegaya Y, Nishiyama N, Matsuki N, and Yamada MK. BDNF locally potentiates GABAergic presynaptic machineries: Target-selective circuit inhibition. Cerebral cortex. 2005;15(3):291-298.


8.    Futatsugi A, Nakamura T, Yamada M, et al. IP3 receptor types 2 and 3 mediate exocrine secretion underlying energy metabolism. Science. 2005;309(5744):2232-2234.


9.    Yamada MK, Nakanishi K, Ohba S, et al. Brain-derived neurotrophic factor promotes the maturation of GABAergic mechanisms in cultured hippocampal neurons. J. Neurosci. 2002;22(17):7580-7585.


10.    Michikawa T, Hirota J, Kawano S, Hiraoka M, Yamada M, et al. Calmodulin mediates calcium-dependent inactivation of the cerebellar type 1 inositol 1,14,5-trisphosphate receptor. Neuron. 1999 1999;23(4):799-808.


11.    Matsumoto M, Nakagawa T, Inoue T, Nagata E, Tanaka K, Takano H, Kuno J, Sakakibara S, Yamada M, et al. Ataxia and epileptic seizures in mice lacking type 1 inositol 1,4,5-trisphosphate receptor. Nature. 1996;379(6561):168-171.


[Reviews]

1.    Yamada MK. (2016) Angiogenesis in refractory depression: A possible phenotypic target to avoid the blood brain barrier. Drug discov ther 10: 79-81.


2.    Yamada, MK. (2016) A link between vascular damage and cognitive deficits after whole-brain radiation therapy for cancer: A clue to other types of dementia? Drug discov ther 10: 74-78.


3.    血管と血のめぐりでの認知症治療の可能性

山田麻紀 香川県薬剤師会会誌「かがやく」学術の頁

かがやく162 p39-41 (2016) 


4.    BDNFと機能的神経ネットワーク

山田麻紀、松木則夫 Clinical Neuroscience 22神経栄養因子その新しい展開 中外医学社 pp287-289 2004


Aya Yokota-Nakatsuma

Google scholarhttps://scholar.google.co.jp/citations?user=wo0aQqUAAAAJ&hl=ja&scioq=aya+yokota-nakatsuma


1.    Yokota-Nakatsuma A. Retinoic Acid Prevents Dendritic Cells from Inducing Novel Inflammatory T Cells That Produce Abundant Interleukin-13. Yakugaku Zasshi. 2017;137(12):1491-1496. doi: 10.1248/yakushi.17-00153.


2.    Yokota-Nakatsuma A, Ohoka Y, Takeuchi H, Song SY, Iwata M. Beta 1-integrin ligation and TLR ligation enhance GM-CSF-induced ALDH1A2 expression in dendritic cells, but differentially regulate their anti-inflammatory properties. Sci Rep. 2016 Nov 29;6:37914. doi: 10.1038/srep37914.


3.    Okayasu I, Hana K, Nemoto N, Yoshida T, Saegusa M, Yokota-Nakatsuma A, Song SY, Iwata M. Vitamin A Inhibits Development of Dextran Sulfate Sodium-Induced Colitis and Colon Cancer in a Mouse Model. Biomed Res Int. 2016;2016:4874809. doi: 10.1155/2016/4874809.


4.    Yokota-Nakatsuma A, Takeuchi H, Ohoka Y, Kato C, Song SY, Hoshino T, Yagita H, Ohteki T, Iwata M. Retinoic acid prevents mesenteric lymph node dendritic cells from inducing IL-13-producing inflammatory Th2 cells. Mucosal Immunol. 2014 Jul;7(4):786-801. doi: 10.1038/mi.2013.96.


5.    Yokota A, Takeuchi H, Maeda N, Ohoka Y, Kato C, Song SY, Iwata M. GM-CSF and IL-4 synergistically trigger dendritic cells to acquire retinoic acid-producing capacity. Int Immunol. 2009 Apr;21(4):361-77. doi: 10.1093/intimm/dxp003.


6.    Mora JR, Iwata M, Eksteen B, Song SY, Junt T, Senman B, Otipoby KL, Yokota A, Takeuchi H, Ricciardi-Castagnoli P, Rajewsky K, Adams DH, von Andrian UH. Generation of gut-homing IgA-secreting B cells by intestinal dendritic cells. Science. 2006 Nov 17;314(5802):1157-60. doi: 10.1126/science.1132742.


Takashi Kubota


1.    Hossain MD, Jamal M, Tanoue Y, Ojima D, Takahashi H, Kubota T, Ansary TM, Ito A, Tanaka N, Kinoshita H, Kishimoto Y, Yamamoto T. (2020) MDGA1-deficiency attenuates prepulse inhibition with alterations of dopamine and serotonin metabolism: An ex vivo HPLC-ECD analysis. Neurosci. Lett. 16, 134677.


2.    Takashi Kubota, Hiroshi Matsumoto, Yutaka Kirino. (2016) Ameliorative effect of membrane-associated estrogen receptor G protein coupled receptor 30 activation on object recognition memory in mouse models of Alzheimer’s J. Pharmacol. Sci., 131, 219-222.


3.    Hajime Shishido*, Yasushi Kishimoto*, Nobuyuki Kawai, Yasunori Toyota, Masaki Ueno, Takashi Kubota, Yutaka Kirino, Takashi Tamiya. (2016) Traumatic brain injury accelerates amyloid-β deposition and impairs spatial learning in the triple-transgenic mouse model of Alzheimer’s disease. Neurosci. Lett. 629, 62-67, (* equal). 


4.    Yasushi Kishimoto, Hajime Shishido, Mayumi Sawanishi, Yasunori Toyota, Masaki Ueno, Takashi Kubota, Yutaka Kirino, Takashi Tamiya, Nobuyuki Kawai. (2016) Data on amyloid precursor protein accumulation, spontaneous physical activity, and motor learning after traumatic brain injury in the triple-transgenic mouse model of Alzheimer's disease. Data in Brief 9, 62-67. 


外部資金獲得実績 最近5カ年


山田麻紀

2021年度-2023年度

科学研究費補助金 基盤研究(C)「生体内での、シナプス可塑性関連分子の入力/病態依存的変動解析」(代表:山田 麻紀)


中妻彩

科研費データベース:https://nrid.nii.ac.jp/ja/nrid/1000030446075/

日本の研究:https://research-er.jp/researchers/view/356674


2016年度-2020年度(2年延長)

科学研究費補助金 基盤研究C「レチノイン酸によるIL-13高産生炎症性Th細胞の制御とアレルギー治療法の研究」(代表:中妻 彩)


2014年度-2016年度

武田科学振興財団 薬学系研究奨励金「新規IL-13高産生炎症性T細胞によるアレルギー炎症性疾患の発症機序の解明」(代表:中妻 彩)


2014年度-2016年度

科学研究費補助金 基盤研究B)「IL-13を高生産する新規炎症性ヘルパーT細胞のアレルギー炎症性疾患における役割」(代表:岩田 誠)


窪田剛志

2016年度-2019年度

科学研究費補助金 基盤研究C「タウタンパク質変異アルツハイマー病モデルマウスの認知能力の精査」(代表:桐野 豊)